Guyot pursued an academic path before turning to motorcycling, obtaining a school-teaching diploma in 1984 and a DEUG in history in 1986. In 1989, at the age of 28, he left teaching to concentrate on motorcycle racing. His debut season saw him compete in the Promosport 350 class on a Yamaha RD 350 LC, winning two races and standing on the podium three times. In 1990 he moved up to Promosport 750, where he claimed three victories.
In 1991, Guyot founded his own team, the Guyot Motorcycle Team, which became known under the acronym GMT94 — the 94 referring to the French department number of Val-de-Marne. He raced for three seasons in the Superbike World Championship during 1991, 1992, and 1993, accumulating 16 starts across those campaigns.
GMT94 became the official Yamaha team in the FIM Endurance World Championship (EWC), and Guyot served simultaneously as rider and team manager. His career as a racer-manager produced some of the team's landmark results. The year 2000 brought GMT94's first 24-hour endurance victory, won at Oschersleben in Germany. In 2001 Guyot won the 24 Hours Motos outright, a feat that made him uniquely the only rider-manager to have claimed that race as of 2017. In 2002 he won the 8 Hours of Brno in the Czech Republic, and in 2004 he took victory at the 8 Hours of Zhuhai in China alongside David Checa and William Costes — the season that delivered Yamaha's first Endurance World Championship title under GMT94's management.
After winning the French Superbike Championship title in 1998 following years of international competition, Guyot stepped back from frontline riding after 2004 to focus on team management. He remained a substitute rider until 2007 and made one further appearance in 2011, winning the 5 Hours of Circuit Carole alongside David Checa in the Trophée Grégory Lemarchal.
After more than a decade at the forefront of endurance racing and having secured three EWC world titles, GMT94 stepped away from the Endurance World Championship following the 2018 season. The team entered the Supersport World Championship in 2018 with Mike Di Meglio and subsequently promoted the young Corentin Perolari. In 2019 GMT94 finished as runner-up in the Supersport World Championship, with Jules Cluzel and Perolari sharing the riding duties throughout the season.
The team's ambitions continued to grow: GMT94 entered the World Superbike Championship in 2023 with Italian rider Lorenzo Baldassarri, marking a new chapter in its competitive evolution.
Alongside his work as a team manager, Guyot has built a prominent career as a television analyst. He has served as a consultant for Eurosport, providing commentary and expert analysis on the World Superbike Championship, Endurance racing, and the British Superbike Championship. Between 2012 and 2018, when Eurosport held MotoGP broadcasting rights, he also appeared on the Dimanche Méca and Warm-up programmes alongside Guenaelle Longy, Christophe Malbranque, and Lionel Rosso. Since 2019, Guyot has continued as an EWC consultant alongside Gilles della Posta, Rémy Tissier, and Romain Hussonnois.
Guyot served on the executive committee of the French Federation of Motorcycling from 2004 to 2008 and again from 2012 to 2016. He has also been involved with the Mutuelle des Motards in youth-facing projects, and works as a Yamaha rider trainer, supervising annual riding lessons at Circuit Carole.
Christophe Guyot's career bridged the disciplines of elite endurance racing, national superbike competition, and international team management across four decades. His GMT94 team became one of the most successful privately run Yamaha operations in European motorcycle sport, with a record that includes three EWC titles, multiple 24-hour race victories, and consistent top-level representation in both endurance and sprint disciplines. His transition into broadcasting after his competitive years ensured continued influence on how French audiences engage with motorcycle racing at the highest level.