Worsham comes from a racing family; his father ran the team that launched his career. He married Connie in February 1999, and they have twin daughters. Based in California, Worsham's career spanned multiple eras of the sport across more than two decades of professional competition.
Worsham made his first professional start at the final race of the 1990 NHRA season in Pomona, California. In 1991, just seven races into his first full campaign, he won the Southern Nationals in Atlanta, becoming the youngest driver in history to win a Funny Car event at age 21. He backed that up with a second win at the Summernationals in Englishtown, New Jersey, and finished sixth in the Funny Car standings at season's end. The NHRA named him Rookie of the Year.
From the mid-1990s onward, Worsham established himself as a top-ten regular in the Funny Car standings. He split time between Funny Car and Top Fuel from 1993 to 1995 before returning exclusively to Funny Car.
His best Funny Car result came in 2004, when he earned five victories, set career-best marks of 41 elimination-round wins, and finished second in the Funny Car championship standings behind John Force. The following three seasons placed him in the top ten, and in 2001, 2002, and 2003 he finished third or fourth consecutively — a run that made him one of Force's most reliable rivals.
In 1998, the NHRA presented Worsham and his family the Blaine Johnson Award, given to the individual, team, or family best demonstrating perseverance and dedication to NHRA drag racing.
At the end of 2008, Worsham joined the Al-Anabi Racing team's Funny Car program. After two seasons — winning three events combined in 2009 and 2010 — the team shifted him to Top Fuel for 2011 when its Funny Car effort was discontinued.
The transition proved dramatically successful. Worsham won his first Top Fuel event at the Gatornationals in Florida, then added further Top Fuel victories across the season. On November 13, 2011, he clinched the NHRA Top Fuel championship at the Auto Club Finals in Pomona, defeating Spencer Massey. One week later he announced his retirement from driving, citing the championship as the goal he had set out to achieve.
After a brief retirement and a stint as crew chief for Kalitta Motorsports' DHL Toyota Camry Funny Car, Worsham returned to driving in late 2012 as the DHL car's pilot. He continued driving for Kalitta through 2016 before rejoining his family team, Worsham Racing, on a Lucas Oil-sponsored Funny Car in 2017.
In 2015, while with Kalitta, Worsham won the NHRA Mello Yello Funny Car championship, making him just the third driver after Kenny Bernstein and Gary Scelzi to win titles in both Top Fuel and Funny Car.
Worsham's dual-championship achievement — separated by four years and spanning the sport's two premier nitro categories — places him in an exclusive tier of NHRA history. His 33 career victories (eight in Top Fuel, 25 in Funny Car) through the first races of the 2011 season, combined with his 2015 Funny Car title, confirm a career defined by adaptability and sustained excellence across the full length of a twenty-plus-year career.