The original Panigale V2 debuted in 2019, built around a 955 cc liquid-cooled 90-degree V-twin engine using Ducati's desmodromic valve actuation system. Its chassis followed the monocoque architecture already established in the Panigale line, with the engine acting as a stressed structural member. The bore and stroke of 100 by 60.8 mm were carried over from the 959, but re-engineering lifted output by 5 hp to a claimed 155 hp (116 kW) while achieving compliance with Euro 5 emissions regulations.
In November 2024, at EICMA in Milan, Ducati unveiled a comprehensively redesigned Panigale V2 for the 2025 model year. Unlike earlier iterations derived from larger superbike platforms, the 2025 version was engineered from scratch as a dedicated middleweight, emphasizing street usability and track agility in equal measure.
At the core of the redesign is an all-new 890 cc 90-degree V-twin engine — named simply "V2" by Ducati — that departs from the desmodromic valve system in favor of conventional spring-actuated valves with finger followers. An intake variable timing (IVT) system supports enhanced torque delivery across the rev range. Claimed output stands at 120 hp (89 kW) at 10,750 rpm and 93.3 Nm (68.8 lbf·ft) at 8,250 rpm, with 70 percent of peak torque available from 3,000 rpm.
The redesign also brought significant weight reduction. Dry weight is claimed at 179 kg (395 lb) for the base model and 176 kg (388 lb) for the V2 S, aided by the new engine — at 54.4 kg (120 lb), Ducati's lightest twin-cylinder unit to date. The chassis is a revised cast aluminum monocoque, and a double-sided swingarm replaces the single-sided unit of earlier generations.
Two variants are offered: the base Panigale V2 with Marzocchi forks and a Kayaba rear shock, and the V2 S with Öhlins NIX30 fork and monoshock alongside a lithium-ion battery. Styling echoes the Panigale V4 family, with full LED lighting and a revised ergonomic layout featuring clip-ons above the triple clamp for improved comfort on road use.
The electronics suite is anchored by a six-axis inertial measurement unit (IMU) managing cornering ABS, traction control, wheelie control, and engine brake control. Four riding modes — Race, Sport, Road, and Wet — are selectable through a 5-inch TFT display. Ducati Quickshift 2.0 enables clutchless up and down shifts. Valve clearance service intervals are extended to 30,000 km (19,000 miles), reducing ownership costs compared to the desmodromic predecessor.
Despite the reduction in peak power relative to the 955 cc model, the 2025 Panigale V2 demonstrated strong track competitiveness. Test rider Davide Stirpe lapped Vallelunga only 0.2 seconds slower than the outgoing 955 cc version, attributing the near-parity result to the redesigned machine's improved agility and braking performance. The model complies with Euro 5+ emissions standards. U.S. pricing at launch was set at $15,995 for the base variant and $18,995 for the V2 S, with deliveries beginning in the first quarter of 2025.