Isotta Fraschini as a marque traces its origins to 27 January 1900, when Cesare Isotta and Vincenzo Fraschini established their company in Milan. By the 1920s the brand had become synonymous with high-end luxury vehicles favoured by film stars and the wealthy elite in North America, and it pioneered the production straight-eight engine in 1919 with the Tipo 8. The original firm entered liquidation in 1949 following the failure of post-war production and the effects of World War II. An industrial engineering continuation — Isotta Fraschini Motori S.p.A., part of the Fincantieri group — kept the name on diesel engines and later fuel cell technology.
The revival of the automotive and motorsport marque came in 2022, when Isotta Fraschini Milano Fabbrica Automobili s.r.l. was established in Milan by former rally drivers Alessandro Fassina and Enzo Panacci, former Lotus executive Claudio Berro, and Michelotto Engineering founder Giuliano Michelotto. The new group confirmed plans to enter Le Mans Hypercar competition in the FIA World Endurance Championship.
Technical partners involved in the Tipo 6 LMH programme included Michelotto Engineering, Williams Advanced Engineering, HWA Team, ARS Technologies, and Xtrac Limited. The car was unveiled in March 2023. A track day variant, the Tipo 6 LMH Pista, was also developed and completed demonstration laps at Paul Ricard during the GT1 Sports Club session as part of the 1000 km of Paul Ricard weekend.
The Tipo 6 LMH was entered in the FIA World Endurance Championship by Vector Sport, but that arrangement fell apart before competition began, with Vector Sport alleging contract breaches by Isotta Fraschini, while the manufacturer cited economic factors for the breakdown. Vector Sport was replaced by the French team Duqueine Team as the race-entering operator.
After an original 2023 debut target was missed, the car competed in five races during its only season in the FIA World Endurance Championship, completing three before the team withdrew from the series ahead of the 2024 Lone Star Le Mans. Internal disputes with Duqueine Team were cited as the reason for the withdrawal. The car's highest finishing result was fourteenth place at the 24 Hours of Le Mans, and the programme scored no championship points during its abbreviated season.
The driver lineup for the Le Mans entry included Carl Bennett, Antonio Serravalle, and Jean-Karl Vernay, the latter a former Pro-Am winner at the 2013 24 Hours of Le Mans.
Two years after the withdrawal from the WEC, Isotta Fraschini entered a partnership with High Class Racing — a Danish endurance racing operation — with the goal of entering the Tipo 6 in the 2026-27 Asian Le Mans Series and planning a potential return to the 24 Hours of Le Mans in a future season.
The Tipo 6 LMH programme represented the most ambitious step in the contemporary revival of the Isotta Fraschini brand, connecting a 120-year-old Italian marque to the pinnacle of modern endurance prototype racing. Although the programme produced limited on-track results and was cut short by organizational disputes, it demonstrated the appetite for established European names to re-enter top-level endurance racing under the Le Mans Hypercar framework. The track-day Tipo 6 LMH Pista variant, alongside a road car model called the Tipo 6 LMH Strada unveiled in 2024, extended the project beyond pure competition into a broader product range.