The team's first season yielded immediate results: Hans Pfeuti won the Swiss Formula Ford 1800 Championship in 1993, the team's founding year. Jenzer Motorsport went on to claim further Swiss Formula Ford titles in 1995, 1996, 1997, 1998, and 2000 with drivers Tazio Pessi, Iradj Alexander, Martin Bünzli, Philipp Mathis, and Walo Schenker respectively. The team also competed in French, EuroCup, and German Formula Ford, with Marc Benz winning the German Formula Ford Championship title in 2000.
In 2000, Jenzer Motorsport transitioned to Formula Renault 2.0 machinery, debuting in the French Formula Renault Championship and expanding to other Formula Renault series. The team made its mark on the Eurocup Formula Renault 2.0, with Marc Benz, Neel Jani, and Michael Ammermüller each finishing as runner-up in 2001, 2002, and 2005 respectively.
In regional Formula Renault competition the team was more consistently successful. Ryan Sharp won the German Formula Renault Championship in 2003, while the Italian Formula Renault Championship yielded titles with Dani Clos in 2006 and Pål Varhaug in 2008. The Swiss Formula Renault Championship produced three consecutive champions: Christopher Zanella in 2008, Nico Müller in 2009, and Zoël Amberg in 2010.
Jenzer also competed in the Formula Renault 3.5 Series from 2003, with Neel Jani finishing as runner-up in the opening season and Ryan Sharp repeating that result in 2004. The team moved to International Formula Masters in 2007 and won the 2009 championship with Fabio Leimer.
After 2009, Jenzer Motorsport left the Formula Renault categories to join both the new-for-2010 Formula Abarth series and the inaugural GP3 Series. In Formula Abarth the team was dominant, winning both the drivers' and teams' titles with Patric Niederhauser in 2011.
In the GP3 Series, Nico Müller's third-place finish in the 2010 Drivers' Championship remained the team's peak result in the category. Niederhauser delivered two race victories in 2012, but the team then went four seasons without a win despite podiums from drivers including Alex Fontana, Mathéo Tuscher, Ralph Boschung, and Arjun Maini. Maini finally returned the team to victory in the 2017 sprint race at Barcelona. The team's 2018 GP3 lineup included Tatiana Calderón, Juan Manuel Correa, and David Beckmann.
When the GP3 Series was rebranded as the FIA Formula 3 Championship in 2019, Jenzer made the transition with it. Yuki Tsunoda was the team's first signed driver for the new formula, followed by Artem Petrov. Tsunoda, who would go on to race in Formula One from 2021, represented one of the most significant drivers the team had developed at that point.
Following its departure from the European Formula Renault categories, Jenzer entered the Italian Formula 4 Championship and the ADAC Formula 4 Championship in 2015. The team continues to operate in the Italian F4 Championship and the Formula 4 CEZ Championship.
Over three decades, Jenzer Motorsport has operated as a consistent presence across the lower tiers of European open-wheel racing. The team's strength has been its ability to identify and develop talent: beyond Tsunoda and Müller, its alumni list includes Neel Jani, Fabio Leimer, and Dani Clos, reflecting a track record of preparing drivers for higher categories even when outright championship success at the top level of its series remained elusive.