Estre grew up in Lyon and began competitive motorsport in karting, winning the French Cadet Championship in 2001 and the European ICA Championship in 2004. He transitioned to single-seaters in 2006, winning the Formula Campus by Renault and Elf series by the narrowest of margins — equal on points with Tristan Vautier across thirteen races. A season in French Formula Renault 2.0 followed in 2007 before he chose to pivot to sportscars.
From 2008, Estre established himself in the Porsche ecosystem through the Porsche Carrera Cup France. He took four seasons in the series, winning race victories at circuits including Magny-Cours, Nogaro, Le Castellet and Circuit de Lédenon. In 2011 he dominated the championship for AS Events, taking ten wins and the title by 113 points. He simultaneously competed in the Porsche Supercup, earning a win at Monza in 2011 and finishing runner-up to René Rast in 2012 with a victory at the Hungaroring. In the ADAC GT Masters, Estre won the support race at the 24 Hours Nürburgring in 2012 and claimed the championship title in 2013 with Attempto Racing, collecting eight wins from seventeen races.
In 2014, Estre briefly stepped away from the Porsche orbit and became a McLaren GT factory driver with ART Grand Prix in the Blancpain Endurance Series, co-driving the McLaren MP4-12C GT3 with Kevin Korjus and Andy Soucek. The crew scored two podiums across the season. For 2015, he competed in the LMP2 class at the 24 Hours of Le Mans with OAK Racing alongside Chris Cumming and Laurens Vanthoor, while continuing in the Blancpain Endurance Series with Von Ryan Racing. He also raced in the Pirelli World Challenge with K-Pax Racing and drove in the 24 Hours of Daytona for Park Place Motorsports that year.
Estre returned fully to Porsche and was confirmed as a factory driver in 2016. In the FIA World Endurance Championship he built a formidable partnership with Michael Christensen, the two winning the LMGTE Pro class manufacturers' and drivers' titles in the 2018–19 extended season — a campaign spanning across the calendar year under the new superseason format.
When Porsche entered the Hypercar class with the 963 for the 2023 WEC season under the Porsche Penske Motorsport banner, Estre was paired with Lotterer and Vanthoor in the No. 6 car. The trio scored podiums at Portimão and Fuji in their debut season, finishing sixth in the standings. In 2024 the three were retained, and the season opened with a commanding victory in Qatar — the programme's first Hypercar win with the 963. The trio went on to claim the 2024 FIA World Endurance Championship Hypercar drivers' title. Outside WEC, Estre also competed at the 2025 24 Hours Nürburgring, finishing second overall after receiving a time penalty. In IMSA he races in the GTP class for Porsche Penske Motorsport.
Estre represents the archetype of a driver who built his career almost exclusively through the Porsche ladder, from national cup racing to the pinnacle of endurance competition. His two WEC titles in different regulatory eras — LMGTE Pro and Hypercar — demonstrate an adaptability rare in GT-specialist drivers. His consistency with the same co-driver pairing (Vanthoor appearing in multiple championship campaigns) reflects the long-term partnership model that has defined Porsche's endurance programme.