Throughout the 1990s, Manor Motorsport established itself as one of the leading junior single-seater outfits in the United Kingdom, competing primarily in Formula Renault. Its alumni during this era include Kimi Räikkönen and Lewis Hamilton, both of whom drove for the team before reaching Formula One, as well as Antônio Pizzonia. A significant milestone came in 1994 when James Matthews won both the British and European Formula Renault series, setting a record of eleven race wins in a single season that stood for more than twenty years.
Manor entered Formula Three in 1999 and immediately demonstrated competitive strength, winning successive British F3 titles with Marc Hynes and Pizzonia. John Booth retained the Manor Motorsport name for the Formula 3 Euro Series operation, which continued until 2009. Following a change of ownership in 2007 — when Formula Renault UK team manager Tony Shaw bought out Booth and continued a separate venture under the Manor Competition name — Booth himself focused on the Formula 3 programme before transitioning to Formula One.
In June 2009, Manor's application to enter the 2010 Formula One season was accepted. The team entered under the name Manor Grand Prix and raced as Virgin Racing for commercial sponsorship reasons, using a Cosworth engine. Their design approach was notable for relying entirely on digital simulation without physical wind tunnel testing, a method later abandoned in 2011 when the team formed a technical partnership with McLaren.
The team was renamed the Marussia F1 Team after Marussia Motors acquired a controlling interest, and competed under that banner from 2012. The organisation's most consequential result in Formula One came in 2014, when Jules Bianchi scored points at the Monaco Grand Prix — the team's first World Championship points. The Japanese Grand Prix later that year brought tragedy when Bianchi suffered severe brain injuries in a collision with a recovery vehicle. He remained in a coma and died in July 2015. From the 2014 Russian Grand Prix onward, the team's cars carried a "JB17" tribute to Bianchi.
The team entered administration following the 2014 Japanese Grand Prix but returned for 2015 after businessman Stephen Fitzpatrick acquired it, with Justin King as chairman. It raced as Manor Marussia that year and, following Booth and Lowdon's departure at the season's end, continued for one final season in 2016 as Manor Racing under independent management before ceasing Formula One operations.
Manor also operated a GP3 Series team from 2010 to 2014 under the Marussia Manor Racing name. In February 2016, the endurance arm of the organisation announced an entry into the FIA World Endurance Championship, fielding two Oreca 05 LMP2 cars powered by Nissan engines. The No. 44 entry ran the full 2016 season with Tor Graves, James Jakes, and Will Stevens.
Manor Motorsport's career traced an arc from grassroots Formula Renault to the pinnacle of Formula One, with the junior programme serving as a springboard for two future world champions. The tragedy of Jules Bianchi's accident and death remains the most sombre chapter of the organisation's history, while the team's persistence through administration and its return for the 2015 season demonstrated Booth and Lowdon's commitment to the project. The Manor Motorsport name has continued in endurance racing through Manor Endurance Racing Ltd.