Ducati comprehensively dominated the season across manufacturer and team categories. With 17 sprint and 19 Grand Prix victories from 20 racing weekends, the Italian manufacturer took their sixth Constructors' World Championship, while the Ducati factory team secured the Teams' World Championship. Japanese manufacturers Honda, Yamaha, and Suzuki's successor projects endured a historically poor campaign, failing to score a single race win for the first time since 1970.
The Riders' Championship produced the closest title fight the modern era had seen in years. Defending champion Francesco Bagnaia and Martín traded the championship lead throughout the season, entering the finale with a 24-point advantage to Martín. Bagnaia swept the concluding round at Barcelona — winning both the sprint and Grand Prix from pole position — but Martín's two third-place finishes were sufficient to seal the title, 508 points to Bagnaia's 498.
Martín took an early lead in Qatar before Bagnaia asserted control in Portugal. Pedro Acosta announced himself to the premier class in that same Portugal round, becoming the youngest rider to achieve a MotoGP-era podium at 19 years and 304 days. Through the European leg, the lead changed hands repeatedly. Maverick Viñales delivered one of the season's landmark results at Austin, completing a perfect weekend for Aprilia and becoming the first rider in MotoGP history to win with three different manufacturers, having previously won with Suzuki and Yamaha.
Bagnaia led the standings by 10 points entering the summer break after Martín crashed from the lead at Sachsenring with two laps remaining. On returning at Silverstone, Enea Bastianini won both races for Ducati while Martín's two second-place finishes allowed him to reclaim the lead. Marc Márquez delivered a landmark performance at Aragon — his first victories in 1,043 days and his first with Ducati — sweeping pole, sprint, and Grand Prix in the same weekend. Márquez then repeated the feat at Misano the following round.
The Asian swing proved decisive. Bagnaia cut the gap to 10 points at Motegi, and the two rivals raced in close combat through Indonesia, Philip Island, Thailand, and Malaysia. At Sepang, the final Asian round, Bagnaia won the main race ahead of Martín to set up the showdown. The Solidarity Grand Prix at Barcelona, replacing the cancelled Valencia round after October flooding, served as the championship finale.
The Valencian Grand Prix, normally the season finale at Cheste, was cancelled following devastating October floods across the Valencia region. A replacement round, named the Solidarity Grand Prix, was held at the Circuit de Barcelona-Catalunya on the date originally set for Valencia, making it an unprecedented two-round visit to the Spanish venue.
The Kazakhstan Grand Prix, scheduled to make its debut after cancellation in 2023, was again abandoned — this time due to incomplete construction at Sokol International Racetrack. Its slot was replaced by a second Misano round. The Argentine Grand Prix was cancelled due to the country's ongoing economic crisis. The 75th anniversary of the World Championship was marked at Silverstone with special retro-inspired liveries worn by all teams in the Grand Prix race.
A new concession system for manufacturers was introduced, classifying constructors by recent performance and adjusting their access to test days, engines, aerodynamic updates, and tyre allocations to support less competitive manufacturers.
Marc Márquez departed Repsol Honda after eleven seasons and six Riders' Championships, joining Gresini Racing on a Ducati alongside brother Álex. Luca Marini moved from VR46 to Repsol Honda, filling the vacancy left by Márquez. Fabio Di Giannantonio joined VR46 Racing Team in Marini's place. Álex Rins moved to Monster Energy Yamaha from LCR Honda, while Johann Zarco moved in the opposite direction. Franco Morbidelli joined Pramac Racing, replacing Zarco. Pedro Acosta entered MotoGP directly with Red Bull GasGas Tech3, replacing the retiring Pol Espargaró.
RNF Racing did not compete after breaching the participation agreement; Trackhouse Racing replaced the outfit as Aprilia's independent team, retaining Miguel Oliveira and Raúl Fernández. At season's end, Aleix Espargaró announced his retirement at Montmeló, where he had ridden for Aprilia, and followed through at the close of the campaign.
Jorge Martín (Prima Pramac Ducati) claimed the Riders' title ahead of Francesco Bagnaia (Ducati) and Marc Márquez (Gresini Ducati). Ducati won the Constructors' Championship and the Ducati factory team won the Teams' Championship.