Hines grew up in a motorsport family with deep roots in NHRA competition. His brother Matt Hines won three consecutive NHRA Pro Stock Motorcycle championships in 1996, 1997, and 1999, setting a standard that Andrew would ultimately surpass. The Vance & Hines team, led by the legendary pairing of Terry Vance and Byron Hines, provided Andrew with the machinery and infrastructure to compete at the front of the field from early in his career. The family and team dynamic made Vance & Hines one of the most cohesive and consistently competitive programs on the NHRA circuit.
Hines made his professional debut at Denver in 2002. He quickly demonstrated that he belonged at the national level, qualifying for every event he entered and advancing to the semifinals at Reading in just his fifth career race. His early-career performance earned him recognition as a finalist for the Auto Club Road to the Future award, the NHRA's Rookie of the Year honor.
By 2003 he was reaching final rounds, finishing runner-up at Sonoma for his first career final-round appearance. The following season, 2004, was the breakthrough year: Hines led the championship standings from start to finish, earned a class-best eight number-one qualifying positions, and won three of four final-round appearances to claim his first Pro Stock Motorcycle world championship — also the first for Harley-Davidson as a manufacturer.
The 2005 season saw Hines become the first rider in Pro Stock Motorcycle history to run a sub-six-second elapsed time, setting national records for both elapsed time (6.968 seconds) and speed (197.45 mph). He won two of five final-round appearances to claim his second consecutive title.
His third championship came in 2006. After a quieter 2007 campaign by his own standards — which still yielded five victories in seven final rounds — Hines won his fourth title in 2014, securing it at the season-ending event in Pomona with six wins and two runner-up finishes during the year. He also won the inaugural MiraMonte Records Pro Bike Battle in Sonoma that season.
Hines achieved additional championships beyond his first four, ultimately reaching six NHRA Pro Stock Motorcycle titles, a figure that stands as one of the most distinguished records in the class's history. He won multiple races in seven consecutive seasons at one point in his career, a streak that demonstrated remarkable longevity and consistency across changing field dynamics and evolving motorcycle technology.
Across his career, Hines set multiple career bests in elapsed time and top speed, and he compiled a record of consistent excellence across more than a decade of competition at the NHRA's highest level. He competed in his 100th career race during the 2008 season.
His induction into the Motorsports Hall of Fame of America in 2022 formally recognized what the record book had long established: Andrew Hines was the definitive Pro Stock Motorcycle champion of his generation, a rider whose combination of team resources, technical preparation, and competitive instinct produced one of the sport's most accomplished careers.