Mann began her career in 2003, signing a three-race contract with Manor Motorsport to race in the winter series of the British Formula Renault Championship. In 2004, she signed with Team JVA and completed a full season, also competing in a European Formula Renault event in Zolder. For 2005, Mann signed a two-year contract to drive for Comtec Racing in the Formula Renault Eurocup and the French Formula Renault 2.0 series, partnering with Westley Barber. She continued with Comtec Racing in 2006 for the UK Formula Renault 2.0 Championship and the Eurocup.
In January 2007, Mann signed for Cram by P1 Europe, becoming the first female to race in the Formula Renault 3.5 Series. In her debut year, she scored a point and started from pole position. She continued to compete in the Formula Renault 3.5 Series in 2008 with the P1 Motorsport team.
Mann signed to drive for Panther Racing in the 2009 Indy Lights series, the development series for the IndyCar Series. During her debut season, she scored a string of top-fifteen finishes, including three top-ten results. After the Panther Racing Indy Lights team closed, Mann decided to remain in Indianapolis and, in December 2009, confirmed she would join Sam Schmidt Motorsports for the 2010 Indy Lights series. In 2010, she became the first female pole sitter for a race at the Indianapolis Motor Speedway by heading the grid for the Indy Lights Freedom 100, and won her first race at Kentucky Speedway.
On March 1, 2011, Mann tested for Conquest Racing at Texas Motor Speedway. On April 19, she announced she would pilot the No. 36 entry for Conquest Racing in the 2011 Indianapolis 500. On May 22 (Bump Day), Mann qualified 32nd, becoming the first British woman to qualify for the 500-mile race. During the race, she moved up twelve positions to finish twentieth, despite a mechanical problem with her on-board water supply that left her severely dehydrated. She was sponsored in the race by Armando Montelongo.
On August 13, 2011, during practice for the MoveThatBlock.com Indy 225 at New Hampshire Motor Speedway, Mann crashed and suffered an end-plate fracture of the C7 vertebra, but still competed on October 2 in the Kentucky Indy 300. On October 16, 2011, Mann was involved in a 15-car chain reaction crash at Las Vegas Motor Speedway. She sustained severe burns to her right little finger and was transported to UMC Southern Nevada for treatment, being released the next day pending later surgery. The crash claimed the life of two-time Indianapolis 500 winner Dan Wheldon and sent J. R. Hildebrand to hospital with a bruised sternum.
In 2012, Mann was close to attempting to qualify for the Indianapolis 500 for Dale Coyne Racing. The team signed her as a third driver for the 2013 edition. In 2013, Mann competed in the Indianapolis 500, driving the No. 18 Cyclops Gear car for Dale Coyne Racing. This marked her second Indy 500 start and first with the team. Cyclops Gear, owned by Mark Krause, partnered with Dale Coyne Racing for this event. Mann finished 30th (out of 33) in the 97th annual Indianapolis 500, completing 46 of 200 laps. She also signed on to make three more large oval race starts with Cyclops Gear and Dale Coyne Racing.
In 2014, Mann qualified 22nd for the 98th Indianapolis 500 as the only female driver in the field and finished 24th (out of 33) for Dale Coyne Racing, in partnership with Susan G. Komen. The partnership allowed fans to donate for each lap Mann completed during the month of May in support of breast cancer research. Despite an issue during an early pit stop, she completed 484 total laps for the month and finished the entire race.
In 2015, Mann returned to Dale Coyne Racing for the 99th Indianapolis 500. She qualified 25th for her fourth appearance with a four-lap average speed of 223.104 mph, starting from the inside of row 9. Mann finished 22nd, again racing for the Susan G. Komen cancer outreach organization. After her Indy race, which raised over $50,000 for cancer, Mann was asked to race again for Dale Coyne Racing in the June 6 Firestone 600. Starting 22nd, she took seventeenth place at Texas Motor Speedway. Dale Coyne Racing continued changing drivers on a race-by-race basis, recalling Mann for the remaining oval tracks. She started 22nd and finished thirteenth on the lead lap at the 2015 MAVTV 500 at Auto Club Speedway. This was the best finish for the No. 18 car midway through the season for the team and one of Mann's best career results since re-joining IndyCar in 2013.
In 2016, Mann was recognized for her achievements both on and off the IndyCar circuit. She was selected by the Susan G. Komen foundation to be on "The List," alongside former First Ladies Laura Bush and Betty Ford, and 29 other public figures, for her efforts in fighting breast cancer. After finishing a career-best eighteenth place in the 100th running of the Indianapolis 500, Mann was also named by Autocar as one of the top 100 British Women in the Car Industry.
In 2017, Mann qualified 28th for the 101st Indianapolis 500 and finished seventeenth. Prior to qualifying on Fast Friday, Mann became the first woman to break the 230 mph barrier around the Indianapolis Motor Speedway by posting a speed of 230.103 mph, according to TrackSide Online. Mann also competed in the 2017 North America Lamborghini Super Trofeo Championship series, where drivers use identical Lamborghini Huracán LP 620-2 cars.
On March 20, 2018, Mann announced her intention to compete in her seventh Indianapolis 500 for Dale Coyne Racing, but she was ultimately bumped from the field. She qualified 30th for the 2019 Indianapolis 500 for Clauson-Marshall Racing, achieving her best-ever finish in the race in sixteenth place. She could not find sponsors to enter the 2020 Indianapolis 500.
Mann has also served as a commentator for IndyCar Radio on the IndyCar Series and Indy Lights series. She also works as a driver coach.
In December 2012, Mann married Robert Gue, an engineer at Schmidt Peterson Motorsports who was formerly the race strategist for James Hinchcliffe.
Pippa Mann is sponsored by Bell Helmets, Cyclops Gear, RockStar Paint, The Momentum Group, Hinchman Racing, ORTHOINDY, Oasis Outdoor, and Dale Coyne Racing.
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