The d'Antin MotoGP team was created in 1999 by Spanish former rider Luis d'Antin and based in Madrid. The team began in the 250 cc class with Yamaha machinery before graduating to the 500 cc class with Norifumi Abe aboard a Yamaha YZR500. Abe won at the Japanese Grand Prix at Suzuka in 2000. When the class became MotoGP in 2002, the team continued with the older two-stroke before receiving the four-stroke Yamaha YZR-M1 for the final races. In 2004, the team switched to Ducati machinery and signed former Superbike World Champion Neil Hodgson alongside Rubén Xaus, though financial difficulties limited their competitiveness.
Owned by the Italian power generator manufacturer of the same name, Pramac Racing first entered MotoGP in 2002, taking over the activities of Hardwick Racing and using the Honda NSR500 with Tetsuya Harada. In 2003, Pramac partnered with the Pons Racing structure, entering Max Biaggi and Makoto Tamada. Biaggi scored two wins that season, and Tamada added two more in 2004, finishing sixth in the championship. Pramac ended that arrangement after 2004 and began a new project with Ducati and d'Antin.
In 2005, d'Antin MotoGP and Pramac Racing formally merged to create Pramac d'Antin, initially fielding Roberto Rolfo on Ducati hardware. Over the following years the team gradually improved its technical alignment with Ducati Corse, eventually receiving factory-specification machinery.
A significant turning point came in 2013 when Pramac received full factory-supported Ducati status, fielding works-specification Desmosedici bikes for Andrea Iannone and Ben Spies. From that point the team consistently served as Ducati's development and satellite programme, nurturing riders who would later move to the factory squad. Danilo Petrucci, Jack Miller, Francesco Bagnaia, and Jorge Martín all rode for Pramac before being promoted or moving to top-level rides elsewhere.
The team's first-ever premier-class race victory came in 2021 when Jorge Martín won the Styrian Grand Prix. In 2023, Pramac Racing won the MotoGP Teams' Championship, becoming the first independent team to claim that title. Martín went on to win the 2024 World Championship with Pramac, making him the first champion to win the title from an independent team in the MotoGP era since Valentino Rossi with Nastro Azzurro Honda in 2001. Pramac also took the Best Independent Team award four consecutive times.
For 2025, Pramac Racing ended its long association with Ducati and aligned with Yamaha as a satellite team, with Jack Miller and Miguel Oliveira riding factory-specification Yamaha machines. The team also entered the Moto2 World Championship as part of its expanded Yamaha relationship. In June 2025, it was announced that World Superbike champion Toprak Razgatlıoğlu would join Pramac for the 2026 MotoGP season, moving across from BMW's Superbike programme, with Miller retaining his seat.
Pramac Racing's trajectory from a marginal squad operating on older machinery to a team capable of winning a riders' world championship and the teams' title represents one of the more remarkable progressions in MotoGP's independent team landscape. The team's long Ducati alliance proved foundational to multiple riders' careers and contributed directly to Ducati's resurgence as a dominant constructor in the premier class.