The circuit was built in 1985 in the municipality of Amozoc, Puebla. Its design pairs an American-style oval — two long straights of 650 metres connected by banked curves with a radius of 118 metres — with a twisty technical infield section that creates a full touring-car road course. The infield surface is notably rough, rewarding tyre-management and strategy alongside outright speed. In total the track offers 18 distinct layout configurations, which have been used by different series at different times throughout its history.
The venue's highest-profile regular series was the World Touring Car Championship, which held rounds at Puebla in 2005, 2006, 2008, and 2009. The WTCC used one specific road-course configuration in 2005 and a different layout for the subsequent events. The 2007 round was cancelled due to problems with the circuit, and the planned 2010 event was also dropped, cited to security and budget concerns in the region. The touring-car circuit's mixed oval-and-infield character creates an unusual compromise for car setup: the banked oval section demands low-drag tuning while the tight infield requires greater downforce, and the abrasive surface places a premium on tyre wear management.
The oval configuration of the Autódromo Miguel E. Abed has hosted more than a dozen NASCAR Mexico Series races over the years, and the track also staged a distinct NASCAR Mexico event using a non-oval configuration on one occasion. The oval is run counter-clockwise in the paperclip style, with the event typically called the Puebla 240. At various points the track has also appeared in discussions around potential IndyCar Series visits, including speculation in 2018 about a possible race on the oval.
In April 2021, it was announced that the circuit would host a Formula E race as a temporary replacement for the Autodromo Hermanos Rodriguez in Mexico City, which at that time was still operating as a field hospital during the COVID-19 pandemic in Mexico. The inaugural Puebla ePrix was held on 19–20 June 2021. For the Formula E layout, the designers took the existing WTCC road-course configuration as a base, adding a tighter hairpin after Turn 3 and introducing an infield loop that rejoined the WTCC layout at Turn 6. The layout also included an attack-mode activation zone routed as an alternate joker lap, which distinguished it from most other Formula E venues.
The track has hosted the 24 Hours of Mexico endurance race since 2006, making it the home of Mexico's premier long-distance event. The combination of a high-speed oval with a technical infield makes the circuit physically demanding for both machinery and drivers over a full 24-hour period.
On 14 June 2009, during a NASCAR Mexico Series race, Carlos Pardo was struck by Jorge Goeters while running in the lead on lap 97 of 100. The collision sent Pardo's car into the end of a lower retaining wall at over 200 km/h. He was airlifted to a local hospital where he was pronounced dead. Despite the fatal crash, race officials awarded Pardo the victory because he had led at the conclusion of the last completed lap before the accident, beating Goeters by 0.044 seconds. Pardo, who had started the race from the final row of the grid, was driving for the Motorcraft team.
The Autódromo Miguel E. Abed continues to host a range of national and regional series. Regular events include the NACAM Formula 4 Championship, the NASCAR Mexico Series, the NASCAR Mikel's Truck Series, and the Gran Turismo Mexico showcase. The facility also operates as a general motorsport centre, offering test-driving programmes, corporate events, driving schools, and a go-kart circuit.