Vettel, who had made a habit of naming his cars, named his RB6 "Luscious Liz". After minor damage was found on that chassis following the Monaco Grand Prix, the team gave Vettel a replacement chassis he named "Randy Mandy". Webber revealed in 2019 to V8 Sleuth in Australia that he had acquired "Luscious Liz" — designated RB6-03 — as part of his contract. That chassis won the Malaysian Grand Prix with Vettel driving and the British and Hungarian Grands Prix with Webber, and was also responsible for the Belgian Grand Prix pole position.
Adrian Newey, Red Bull Racing's chief technical officer, later described the RB6 as "probably the car with the most downforce in the history of F1". The car was powered by a Renault V8 engine. The RB6 was the last customer-engined Formula One car to win the constructors' title, a distinction that stood until the Mercedes-powered McLaren MCL38 won it in 2024. From 2011 to 2015 Red Bull Racing was officially promoted to a Renault full-works partnership. The RB6 was also the first Renault-powered car outside the Enstone-based full-works team to win the constructors' title since the Williams FW19 in 1997.
In qualifying the RB6 set the fastest time in 15 of the 19 rounds. At the Bahrain Grand Prix Vettel took pole and led until lap 33, when a spark plug problem reduced his pace and dropped him to fourth; Webber finished eighth. In Australia a loose wheel nut ended Vettel's race while leading; Webber finished ninth after a late incident with Lewis Hamilton. In Malaysia the team scored a dominant 1–2, Vettel winning. In Spain Webber took pole and won, with Vettel third after a brake problem in the final eight laps. In Monaco Webber again took pole and dominated; Vettel finished second after passing Robert Kubica's Renault on lap one.
In Turkey, Webber held pole for a third consecutive round. On lap 40 Vettel and Webber collided during an attempted overtake by Vettel, ending Vettel's race and Webber's victory chance; Hamilton won from Jenson Button with Webber third. Red Bull surrendered the constructors' lead to McLaren by one point. In Canada both cars finished only fourth and fifth, dropping the team 22 points behind. In Valencia Vettel won his first race since Malaysia; Webber was involved in a 190 mph collision with Heikki Kovalainen, flipping over an advertising board, but escaped unhurt.
At Silverstone, Red Bull brought two updated front wings. After one was damaged in practice, the second was given to Vettel for qualifying based on championship position and practice pace, leaving Webber frustrated. Vettel qualified on pole; Webber made a better race start and led, while Vettel suffered a puncture from contact with Hamilton's front wing endplate and recovered to seventh. Webber won and told his team on the slow-down lap that his victory was "not bad for a number two driver", adding in the press conference that he would not have signed a contract extension had he expected to be treated unfavourably. Vettel took poles in Germany and Hungary but finished third in both; Webber won Hungary after Vettel received a drive-through penalty for falling more than ten car-lengths behind during a safety car period, returning Webber to the top of the drivers' standings and Red Bull to the constructors' lead.
In Belgium Webber took pole and finished second behind Hamilton; Vettel damaged his front wing attempting to pass Button, pitted, then took a puncture from Vitantonio Liuzzi's front wing and finished a lap down in 15th. At Monza both drivers had poor starts; Webber recovered to sixth, Vettel to fourth with a clever strategy, and Webber retook the championship lead after Hamilton retired. In Singapore Vettel qualified second, finished just two tenths behind Fernando Alonso, and Webber moved through the field to third despite colliding with Hamilton.
In Japan Red Bull dominated every session except rain-disrupted Saturday practice, locking out the front row. Vettel led from pole and Webber regained second after Kubica's early retirement. Jenson Button ran an alternate strategy and led without pitting until late, at which point the Red Bulls resumed their 1–2. Webber set the fastest lap on the final lap. In Korea both Red Bulls failed to finish: Webber crashed early and collected Nico Rosberg's Mercedes; Vettel suffered an engine failure while leading with ten laps remaining. In Brazil Vettel won from second on the grid with Webber second, securing the constructors' championship. At Abu Dhabi Vettel clinched his maiden drivers' world title by winning from pole, while Webber finished eighth and championship rivals Alonso and Webber were both eliminated from contention.
The RB6 claimed Red Bull Racing's first World Constructors' Championship and delivered Vettel his first World Drivers' Championship. The constructors' title was the first of four consecutive titles Red Bull Racing would win. Vettel stated in 2014, before his final race with the team, that the RB6 was his favourite Formula One car to drive to that point in his career.
The car appears in the video game F1 2010. In June 2017 Codemasters announced it would reappear in F1 2017 as a classic car, and in July 2018 it was confirmed for F1 2018. It also appeared in F1 2019 and F1 2020 as a classic car.
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