After the troubled Yamaha V12 programme with Jordan in 1992, Yamaha revised their Formula One approach and developed a new V10 unit designated the OX10A. The engine was taken up by Tyrrell Racing, a team with a long history in Formula One but operating with limited resources by the early 1990s. Tyrrell provided Yamaha with a stable platform for continued development, and the Japanese manufacturer provided engines at competitive rates that helped the team's budget situation.
The OX10A made its competitive debut mid-season in 1993, initially powering the Tyrrell 020C that replaced the older 020 chassis from the British Grand Prix onwards. Drivers Ukyo Katayama and Andrea de Cesaris used the updated car for the remainder of the year. Neither driver scored a World Championship point in the 020C, and the season overall was a difficult one for Tyrrell. The team then introduced the Tyrrell 021, also powered by the OX10A, for the second half of 1993, again without scoring points.
For 1994, Tyrrell introduced the 022 chassis designed by Harvey Postlethwaite and Mike Gascoyne, powered by a revised OX10B derivative. Drivers Ukyo Katayama and Mark Blundell contested the season with this combination. The 022 proved to be Tyrrell's most competitive package of the period, with Blundell achieving a podium — a third place at the Spanish Grand Prix — which would prove to be the team's final podium finish in Formula One history. Katayama also showed improved pace, qualifying competitively on occasion. The combination of the 022 chassis and the Yamaha V10 represented the high-water mark of the Tyrrell-Yamaha partnership.
The switch to 3.0-litre regulations for 1995 required engine manufacturers to develop new or substantially revised units. Tyrrell ran a 3.0-litre variant of the Yamaha V10 — related to the OX10 family — in the 023 chassis, designed again by Postlethwaite and Gascoyne. The car featured an innovative hydraulic front suspension system known as Hydrolink, though this proved ineffective and was removed mid-season. Mika Salo, joining the team from Lotus, scored all five of Tyrrell's championship points during the year, with fifth-place finishes at the Italian and Australian Grands Prix representing the best results. Katayama was significantly outpaced by his younger teammate throughout the season.
The OX10 engine family provided Yamaha with several seasons of competitive data and race mileage in Formula One. While the results achieved with Tyrrell were modest, the partnership allowed Yamaha to refine their V10 architecture across a sustained programme. Tyrrell's limited budget and chassis performance placed a ceiling on what was achievable, and Yamaha's engine was never able to demonstrate its true potential against the works Renault and Ferrari units that dominated the era. Tyrrell and Yamaha ended their association at the close of the 1995 season.