Briscoe's father Kevin initially did not allow him to race but later relented. At the age of thirteen Briscoe drove 410 sprint cars, recording seventeen top-ten finishes and winning the final race of the season, becoming the youngest driver to win a 410 sprint car race — beating NASCAR champion Jeff Gordon's record by one year — using an engine from 1993.
In 2013, Briscoe applied for the Peak Stock Car Dream Challenge, a contest offering a ride at Michael Waltrip Racing; despite winning the majority of on-track races, he finished second behind Patrick Staropoli. Ty Norris of Michael Waltrip Racing told Briscoe after the fact that he should still pursue a racing career. Later in 2013, Briscoe made his NASCAR K&N Pro Series West debut at NAPA Speedway, finishing eighth, then ran two further races at Kern County Raceway Park and Phoenix International Raceway. He moved from Indiana to Charlotte, North Carolina in 2014.
In 2015, contact from Christopher Bell led Briscoe to a test with Cunningham Motorsports in the ARCA Racing Series. After tests at Mobile International Speedway and Fairgrounds Speedway, he made his ARCA debut at Lucas Oil Raceway at Indianapolis (tenth) and his second start at Salem Speedway (fifth). He formed a personal friendship with Briggs Cunningham III and was offered a full-season ride for 2016. Briscoe won six races and claimed the 2016 ARCA Racing Series championship by 535 points over runner-up Tom Hessert.
In 2017, Briscoe joined the Ford Performance NASCAR Driver Development Program and Brad Keselowski Racing, driving the No. 29 Cooper Standard-sponsored Ford F-150 full-time in the Camping World Truck Series. He finished third at Daytona on debut, earned his first career Truck Series pole at Dover International Speedway, and took his first career win at Homestead-Miami Speedway. He was named the Truck Series' Most Popular Driver in 2017. Brad Keselowski Racing shut down after the season, leaving Briscoe without a ride. Before that season, Hendrick Motorsports had offered Briscoe a seat, but he could not bring sufficient sponsorship.
In 2018, Briscoe ran a part-time Xfinity schedule in the No. 60 Ford of Roush Fenway Racing and the No. 98 Ford of Stewart-Haas Racing. He won the inaugural Xfinity race on the Charlotte Roval, holding off Justin Marks and Austin Cindric. He also drove the No. 27 ThorSport Racing truck at Eldora Speedway, winning in a photo finish over teammate Grant Enfinger, and returned to the same team for the same race in 2019, finishing seventh.
Briscoe committed to a full-time 2019 Xfinity schedule in SHR's No. 98, earning his second career series win at Iowa Speedway in July and qualifying for the 2019 NASCAR Xfinity Series Playoffs on the back of ten consecutive top-ten finishes. He finished the season fifth in points.
In 2020, Briscoe won nine Xfinity races — the most by any driver that year, the most by a Ford driver in the series, and the second-highest by a non-Cup driver since Sam Ard in 1983. Victories came at Las Vegas, Darlington, Homestead, Pocono Raceway, Indianapolis Motor Speedway (the inaugural infield road course race), Dover International Speedway, Bristol, Las Vegas (fall), and Kansas. The Darlington win, which came after his wife Marissa suffered a miscarriage, was an emotionally charged moment: Briscoe broke down after exiting his car rather than celebrating. He finished the season fourth in points.
On October 20, 2020, Stewart-Haas Racing announced Briscoe would be promoted to the Cup Series in 2021, replacing Clint Bowyer in the No. 14 Ford Mustang. His first top ten came at Circuit of the Americas (sixth). In the inaugural Bristol dirt race he drove the No. 04 for Roper Racing. He also made appearances in the Xfinity Series, the ARCA Menards Series West at Sonoma Raceway (where he led every lap to win in the No. 14, the same car number and crew chief as his Cup entry), and the main ARCA Series at Watkins Glen (where he led nine laps before a suspension issue ended his race in 23rd). Briscoe finished 23rd in the final Cup standings and won Rookie of the Year honors.
Briscoe and the No. 14 carried Mahindra Tractors sponsorship for the majority of the season. He placed third at the Daytona 500, missing the win by 0.091 seconds behind Bubba Wallace and winner Austin Cindric. On March 13, Briscoe won his first Cup Series race at Phoenix, leading 101 of 312 laps — becoming the 200th different driver to win a Cup Series race. He was eliminated in the Round of 8 after finishing tenth at Martinsville, and closed the season ninth in the points standings, a career best.
Briscoe started 35th (DNF) at the Daytona 500. On May 31, following the Coca-Cola 600, NASCAR issued an L3 penalty on the No. 14 after a post-race inspection revealed a counterfeit engine panel NACA duct; the team was docked 125 owner and driver points and 25 playoff points, and crew chief Johnny Klausmeier was suspended for six races and fined US$250,000.
Briscoe started the Daytona 500 tenth. He broke a 73-race winless streak at the Southern 500 to re-enter the playoffs. On May 28, 2024, Stewart-Haas Racing announced it would shut down its NASCAR operations at the end of the season.
On June 25, 2024, it was announced Briscoe would replace Martin Truex Jr. in the No. 19 Toyota at Joe Gibbs Racing for 2025. He started the Daytona 500 from pole and finished fourth; the car was subsequently found to have a modified spoiler and Briscoe was penalised 100 driver points and 10 playoff points — JGR was fined US$100,000 and crew chief James Small was suspended four races. On March 5, JGR successfully appealed the penalty, restoring all points, money, and lifting Small's suspension.
Briscoe won the pole for the 2025 Coca-Cola 600, becoming the first driver since William Byron in 2019 to win both the Daytona 500 and Coca-Cola 600 poles in the same season. He added back-to-back poles at Nashville and Michigan, and also took the pole for the Brickyard 400 — making him the first driver to start from the front in three consecutive Crown Jewel events in the same year. On June 22, Briscoe scored his first win with JGR at Pocono, holding off teammate Denny Hamlin to lock in playoff eligibility. He won again at Darlington (Round of 16) and Talladega (Round of 8), advancing to the Championship 4. He is also the 2025 Southern 500 winner.
Briscoe began the 2026 season with a DNF at the Daytona 500 (36th) and a runner-up finish at Atlanta. He also drove the No. 19 for JGR in the O'Reilly Auto Parts Series at Las Vegas, filling in for Brent Crews, and returned to the Craftsman Truck Series in the No. 5 for Tricon Garage at Bristol.
Briscoe's father Kevin is a former Truck Series driver and a five-time track champion at Tri-State Speedway and Bloomington Speedway; his grandfather Richard worked as a car owner for drivers including Rich Vogler and Dave Blaney. Briscoe met Christopher Bell through iRacing. He is an active Reddit user and interacts with fans on the NASCAR subreddit. He is married to Marissa; the couple suffered a miscarriage in May 2020. On March 25, 2021, Marissa announced a pregnancy; their son was born October 2, 2021. On October 8, 2024, Marissa gave birth to boy/girl twins.
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