Suárez began karting in 2002 and won a class championship in 2007 before moving into NASCAR Mexico competition. He won the NASCAR Mexico Mini-Stock category in 2008 as the youngest winner in that series. In 2010 he earned Rookie of the Year honours in the NASCAR Mexico Series for Telcel Racing. After competing in the NASCAR K&N Pro Series East from 2011, he won his first K&N East race at Columbus Motor Speedway in 2013 while competing for Rev Racing, finishing third in the K&N championship and runner-up in the NASCAR Toyota Series. He was named to NASCAR's Drive for Diversity programme in 2013. Joe Gibbs Racing selected him for a Nationwide Series debut at Richmond International Raceway in April 2014.
Suárez competed full-time in the NASCAR Xfinity Series in 2015 driving the No. 18 Toyota for Joe Gibbs Racing, winning the Rookie of the Year title. In 2016 — now in the No. 19 car — he won his first Xfinity race at Michigan, passing Kyle Busch on the final lap to become the first Mexican-born winner in a NASCAR national touring series. He clinched the 2016 Xfinity championship at Homestead, the first foreign-born driver to win a NASCAR national series title. He also won his first Camping World Truck Series race at Phoenix in November 2016.
After Carl Edwards' retirement, Suárez drove the No. 19 Toyota for Joe Gibbs Racing in 2017, achieving a career-best sixth at Dover. He scored his first Cup Series pole at Pocono in 2018. On November 7, 2018, it was announced that Martin Truex Jr. would replace him for 2019.
Suárez drove the No. 41 Ford for Stewart–Haas Racing in 2019 and the No. 96 Toyota for Gaunt Brothers Racing in 2020, struggling at both teams. In 2021 he joined Justin Marks's Trackhouse Racing in the No. 99 Chevrolet, scoring Trackhouse's first top-five at the Bristol dirt race.
At Sonoma Raceway in 2022, Suárez became the first Mexican-born Cup Series race winner. He finished the 2022 season a career-best tenth in points. His second Cup win came at Atlanta Motor Speedway in February 2024, by 0.003 seconds over Ryan Blaney — the fourth-closest finish in Cup history. On October 22, 2025, it was announced Suárez would join Spire Motorsports in the No. 7 Chevrolet for 2026.
Suárez resides in Huntersville, North Carolina. In 2024 he married Julia Piquet, daughter of three-time Formula One world champion Nelson Piquet. In June 2024 he became a dual citizen of Mexico and the United States. In 2017 he voiced the character Daniel "Danny" Swérvez in Pixar's Cars 3.
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