The AMR22 is the first car that has been overseen by new team principal, Mike Krack formerly of BMW Motorsport, who replaced Otmar Szafnauer, who joined Alpine. Dan Fallows joined the development team in April 2022, leaving Red Bull Racing to become Aston Martin's technical director. The AMR22 was first fired up on 4 February ahead of a launch on 10 February at the Aston Martin headquarters in Gaydon, United Kingdom. The following day, drivers Sebastian Vettel and Lance Stroll completed a shakedown at Silverstone Circuit.
Upon launch, the AMR22 was noted for its wide body, using the full width of the available floor. It featured sidepod radiators with a deep cut and a double floor design. The engine was mounted towards the back, indicated by the plenum blister, suggesting a small gearbox. The car had cooling vents along the entirety of the upper sidepod, with front openings described as small boxes compared to previous cars.
The AMR22 was part of the official pre-season test in Bahrain, where 339 laps were completed, with Vettel achieving a fastest time of 1:33.821. At the second test in Barcelona, both Vettel and Stroll performed testing duties, managing a combined total of 296 laps.
Prior to the opening round of the season, Sebastian Vettel was replaced for the race by Nico Hülkenberg due to his contraction of COVID-19. At the first race, neither car finished in the points scoring positions. At the second round in Saudi Arabia, both cars finished the race but again, neither scored points. Vettel returned for the Australian Grand Prix but retired from the race.
The AMR22 scored points at the 2022 Emilia Romagna Grand Prix with an 8th and 10th-place finish. Stroll scored 10th place and a single point at the Miami Grand Prix and his home race in Canada, whilst Vettel secured points finishes at Monaco, Azerbaijan, and Britain. To celebrate Aston Martin's 100 years in motor racing, the AMR22 featured the marque's historic badge on its nosecone for the French Grand Prix. In the race, Stroll scored a point after a close last-lap battle with teammate Vettel. The team secured a double points score at the Singapore Grand Prix, with Stroll in 6th and Vettel in 8th. The team finished in 7th place in the constructors' standings, with Alfa Romeo finishing 6th on countback.
At the Spanish Grand Prix, the AMR22 was significantly updated and changed, with a design similar to the Red Bull. The FIA confirmed the upgrades were legitimate. Andrew Green confirmed that the team had been working on two differing designs for the AMR22 over a six-month period. In June, driver Lance Stroll confirmed that there were further developments planned for the AMR22.
In late July, Vettel announced he would be retiring from Formula One at the end of the season. The AMR22 would be the final car driven competitively by the four-time world champion.
The AMR22 once again featured title sponsorship and branding from Cognizant. Aramco and Crypto.com both joined the team as senior partners with branding across the vehicle, and Aramco joined the team's official name. Prior to the BWT sponsorship being switched to Alpine, the pink stripe was replaced with a light lime stripe.
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